I am using Big Sur and get the message:
Box Drive failed to initialize with macOS. Please relaunch the application to resolve the issue. If the problem persists, please contact Box Support to further troubleshoot.
This is a long time problem. I tried everything tech support told me. I reset the app, reinstalled, etc. So I gave up and deinstalled and quit using box entirely for many months. I tried reinstalling again and I have the same problem. I'm hoping someone can figure this out.